H2N2V1, France, Analysis, bibRecord, 000025

Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study

Identifieur interne : 000025 ( France/Analysis ); précédent : 000024; suivant : 000026

Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study

Auteurs : V. Busignies [France] ; G. Simon [France] ; G. Mollereau [France] ; O. Bourry [France] ; V. Mazel [France] ; Manuel Rosa-Calatrava [France] ; P. Tchoreloff [France]

Source :

International Journal of Pharmaceutics [ 0378-5173 ] ; 2018-03.

RBID : Hal:hal-01953648

Descripteurs français

Wicri :
- topic : Porcin, Vaccination.

English descriptors

mix :
- Animals, Female, H1N1 Subtype, Influenza A Virus, Influenza Vaccines, Influenza virus, Injections, Intramuscular, Male, Mouth Mucosa, Mucosal vaccination, Orthomyxoviridae Infections, Pig, Pre-clinical evaluation, Swine, Tablets, Vaccination, Vaccine tablet.

Abstract

Liquid vaccine formulations present some disadvantages such as stability problems, cold chain requirement or administration by trained personnel. Vaccine formulated as tablets would present a wide range of progress such as an increase stability that would facilitate the administration, the distribution and the storage of vaccine formulations. This work investigates the possibility to develop a mucosal tablet vaccine for human influenza viruses. The tablets were tested in vitro for biological efficacy and stability and in vivo in swine as a model for influenza A virus immunity. First, the ability to produce by compaction a stable vaccine with a preserved antigen was demonstrated. In a second part, vaccine tablets were used to immunize pigs. After positioning the tablets on the buccal mucosa, the animals were challenged by inoculation of the A/H1N1 pandemic virus. The responses were compared to those observed in animals vaccinated intramuscularly with the commercial liquid vaccine. It was observed signs of priming of the pig's immune system with vaccine tablets, even if the immune response stayed lower than vaccination by intramuscular route. Thus, we present attractive results that indicate a promising potential for mucosal vaccine tablets.

Url:

https://hal.archives-ouvertes.fr/hal-01953648

DOI: 10.1016/j.ijpharm.2018.01.021

Affiliations:

Links toward previous steps (curation, corpus...)

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Links to Exploration step

Hal:hal-01953648

Le document en format XML

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          <date type="start">2010</date>
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          <date type="end">2019-12-31</date>
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</tutelle>
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          <desc>            <address>              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
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</tutelle>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Rosa Calatrava, Manuel" sort="Rosa Calatrava, Manuel" uniqKey="Rosa Calatrava M" first="Manuel" last="Rosa-Calatrava">Manuel Rosa-Calatrava</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-543794" status="VALID">          <orgName>Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control</orgName>
          <orgName type="acronym">Virpath</orgName>
          <date type="start">2016-01-01</date>
          <desc>            <address>              <addrLine>Laboratoire de Virologie et Pathologies humaines – VirPathFaculté de médecine RTH LaennecBâtiment B7-11 rue Guillaume Paradin69372 Lyon cedex 08</addrLine>
              <country key="FR"></country>
            </address>
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          </desc>
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          <idno type="RNSR">201320572J</idno>
          <orgName>Centre International de Recherche en Infectiologie - UMR</orgName>
          <orgName type="acronym">CIRI</orgName>
          <date type="start">2013-01-01</date>
          <desc>            <address>              <addrLine>21 avenue Tony Garnier 69365 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://ciri.inserm.fr/</ref>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
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          <orgName>École normale supérieure - Lyon</orgName>
          <orgName type="acronym">ENS Lyon</orgName>
          <desc>            <address>              <addrLine>15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.ens-lyon.eu/</ref>
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</tutelle>
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          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>            <address>              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
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          <desc>            <address>              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
<author><name sortKey="Tchoreloff, P" sort="Tchoreloff, P" uniqKey="Tchoreloff P" first="P." last="Tchoreloff">P. Tchoreloff</name>
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          <idno type="IdRef">15505113X</idno>
          <orgName>Institut de Mécanique et d'Ingénierie de Bordeaux</orgName>
          <orgName type="acronym">I2M</orgName>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <addrLine>Site ENSCBP Bât A 16 avenue Pey-Berland 33607 Pessac Cedex</addrLine>
              <country key="FR"></country>
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            <ref type="url">http://i2m.u-bordeaux.fr/</ref>
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            </address>
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          <date type="start">2020-03-04</date>
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              <country key="FR"></country>
            </address>
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          </desc>
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</tutelle>
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          <orgName type="acronym">HESAM</orgName>
          <date type="start">2010</date>
          <desc>            <address>              <addrLine>15, rue Soufflot75005 Paris</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.hesam.eu</ref>
          </desc>
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</tutelle>
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              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="USC1368 " active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD">          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
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</tutelle>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
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          </desc>
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</tutelle>
<tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID">          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>            <address>              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.ijpharm.2018.01.021</idno>
<series><title level="j">International Journal of Pharmaceutics</title>
<idno type="ISSN">0378-5173</idno>
<imprint><date type="datePub">2018-03</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>H1N1 Subtype</term>
<term>Influenza A Virus</term>
<term>Influenza Vaccines</term>
<term>Influenza virus</term>
<term>Injections</term>
<term>Intramuscular</term>
<term>Male</term>
<term>Mouth Mucosa</term>
<term>Mucosal vaccination</term>
<term>Orthomyxoviridae Infections</term>
<term>Pig</term>
<term>Pre-clinical evaluation</term>
<term>Swine</term>
<term>Tablets</term>
<term>Vaccination</term>
<term>Vaccine tablet</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Porcin</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Liquid vaccine formulations present some disadvantages such as stability problems, cold chain requirement or administration by trained personnel. Vaccine formulated as tablets would present a wide range of progress such as an increase stability that would facilitate the administration, the distribution and the storage of vaccine formulations. This work investigates the possibility to develop a mucosal tablet vaccine for human influenza viruses. The tablets were tested in vitro for biological efficacy and stability and in vivo in swine as a model for influenza A virus immunity. First, the ability to produce by compaction a stable vaccine with a preserved antigen was demonstrated. In a second part, vaccine tablets were used to immunize pigs. After positioning the tablets on the buccal mucosa, the animals were challenged by inoculation of the A/H1N1 pandemic virus. The responses were compared to those observed in animals vaccinated intramuscularly with the commercial liquid vaccine. It was observed signs of priming of the pig's immune system with vaccine tablets, even if the immune response stayed lower than vaccination by intramuscular route. Thus, we present attractive results that indicate a promising potential for mucosal vaccine tablets.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Nouvelle-Aquitaine</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Bordeaux</li>
<li>Lyon</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université de Bordeaux</li>
<li>Université de Lyon</li>
</orgName>
</list>
<tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Busignies, V" sort="Busignies, V" uniqKey="Busignies V" first="V." last="Busignies">V. Busignies</name>
</region>
<name sortKey="Bourry, O" sort="Bourry, O" uniqKey="Bourry O" first="O." last="Bourry">O. Bourry</name>
<name sortKey="Mazel, V" sort="Mazel, V" uniqKey="Mazel V" first="V." last="Mazel">V. Mazel</name>
<name sortKey="Mollereau, G" sort="Mollereau, G" uniqKey="Mollereau G" first="G." last="Mollereau">G. Mollereau</name>
<name sortKey="Rosa Calatrava, Manuel" sort="Rosa Calatrava, Manuel" uniqKey="Rosa Calatrava M" first="Manuel" last="Rosa-Calatrava">Manuel Rosa-Calatrava</name>
<name sortKey="Simon, G" sort="Simon, G" uniqKey="Simon G" first="G." last="Simon">G. Simon</name>
<name sortKey="Tchoreloff, P" sort="Tchoreloff, P" uniqKey="Tchoreloff P" first="P." last="Tchoreloff">P. Tchoreloff</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study
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Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study

Development and pre-clinical evaluation in the swine model of a mucosal vaccine tablet for human influenza viruses: A proof-of-concept study

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